October 23 - 26, 2025   Radisson Blu Aqua Hotel, Chicago

Agenda

All times listed are Central Time Zone.

Thursday, October 23

8:00 AM Breakfast & Check-in
9:00 AM Welcome
William Gradishar, MD
SESSION 1
New Considerations in Breast Cancer
Session Moderator: Nora Hansen, MD
9:05 AM Obesity, Menopause, Metabolic Biomarkers
Erin Giles, PhD
9:35 AM GLP-1 Drugs and Breast Cancer
Neil Iyengar, MD
10:05 AM Sustainability and Breast Cancer
Martin O’Sullivan, MD
10:35 AM AI Tools for Clinical Practice
Emily Ray, MD
11:05 AM Controversies in Breast Reconstruction
Babak Mehrara, MD
11:35 AM Q&A
12:00 PM Lunch
1:00 PM Awards
SESSION 2
Breast Pathology for the Non-Pathologist
Session Moderator: Kalliopi Siziopikou, MD, PhD
1:15 PM The Ever-Changing Field of Breast Tumor Biomarkers
Hannah Wen, MD, PhD
1:45 PM The Spectrum of the Phyllodes Tumors of the Breast
Bill Li, MD, PhD
2:15 PM Diagnostic Pitfalls in Breast Pathology
Ashley Cimino-Mathews, MD
2:45 PM Artificial Intelligence (AI) in Breast Pathology; Excitement and Doubts
Kalliopi Siziopikou, MD, PhD
3:15 PM Q&A
3:35 PM Break
3:55 PM Unusual Cases Panel
Moderator: William Gradishar, MD; Panel: Confirmed speakers
5:15 PM Adjourn

View more agendas: Thursday | Friday | Saturday | Sunday | Non-CME

Friday, October 24

7:30 AM Breakfast & Check-in
SESSION 3
Imaging & Risk
Session Moderator: Seema Khan, MD
8:30 AM Genetic Syndromes Associated with Male Breast Cancer
Claudine Isaacs, MD
9:00 AM Molecular Underpinnings of Disparity in Breast Cancer
Neha Goel, MD
9:30 AM Imaging Strategies to Reduce Disparity
Maxine Jochelson, MD
10:00 AM Break
10:20 AM PET Scanning with Newer Tracers
Gary Ulaner, MD
10:50 AM Q&A
11:10 AM LYNN SAGE DISTINGUISHED LECTURE
From Radical to Rational: The Remarkable Evolution of Loco-regional Management in Breast Cancer
Terry Mamounas, MD
12:10 PM Lunch
SESSION 4
Challenges in Lobular Carcinoma and Optimal Endocrine Therapy
Session Moderator: Janice Lu, MD
1:30 PM Biology of Lobular Cancer
Steffi Oesterreich, PhD
2:00 PM Surgical Issues in Lobular Cancer
Tari King, MD
2:30 PM Systemic Issues in Lobular Cancer
Rachel Jankowitz, MD
3:00 PM Break
3:20 PM Sequencing Endocrine Therapy in HR+ Disease
William Gradishar, MD
3:50 PM Novel SERDS
Virginia Kaklamani, MD, DSc
4:20 PM Q&A
4:45 PM Adjourn

View more agendas: Thursday | Friday | Saturday | Sunday | Non-CME

Saturday, October 25

7:30 AM Breakfast & Check-in
SESSION 5
Triple Negative Breast Cancer
Session Moderator: William Gradishar, MD
8:30 AM Mimics of TN Breast Cancer
Edi Brogi, MD
9:00 AM Managing Non-pCR after NAC
Joyce O’Shaunghnessy, MD
9:30 AM Selecting the Right RT for the Right patient
TBA
10:00 AM Systemic Therapy for TN Cancer in 2025
Heather McArthur, MD
10:30 AM Break
11:00 AM Management of the Axilla after NAC: ITCS,Micrometastases, and Macrometastases
Tracy Moo, MD
11:30 AM Q&A
12:00 PM Lunch
SESSION 6
Controversies in Management
Session Moderator: Jonathan Stauss, MD, MBA
1:15 PM Molecular Minimal Residual Disease
Dan Stover, MD
1:45 PM Primary Endocrine Therapy 2025
Anthony Elias, MD
2:15 PM Cryoablation for Local Control
Sheldon Feldman, MD
2:35 PM Preoperative RT to Facilitate Reconstruction
Audree Tadros, MD
2:55 PM Q&A
3:25 PM Case Management Panel
Moderators: Monica Morrow, MD; William Gradishar, MD; Panel: Nora Hansen, MD; Armando Giuliano, MD; Anthony Elias, MD; Eric Donnelly, MD
5:00 PM Adjourn

View more agendas: Thursday | Friday | Saturday | Sunday | Non-CME

Sunday, October 26

7:30 AM Breakfast & Check-in
SESSION 7
Omitting Surgery – The Ultimate De-escalation
Session Moderator: Monica Morrow, MD
8:30 AM Omitting Sentinel Node Biopsy: Multidisciplinary Concerns - What does the data say?
Armando Giuliano, MD
9:00 AM Radiation Oncology Concerns
Atif Khan, MD
9:30 AM Medical Oncology Concerns
Hal Burstein, MD
10:00 AM Is it time to abandon surgery in DCIS?
Monica Morrow, MD
10:30 AM Q&A
11:00 AM Adjourn

View more agendas: Thursday | Friday | Saturday | Sunday | Non-CME

Friday

Saturday

Sunday

Non-CME Educational Activities

Optional educational activities are scheduled during times that do not conflict with the Symposium agenda and are not approved for CME or continuing education credit. The content of these optional non-CME activities and opinions expressed by presenters are those of the sponsor or presenters. Meals will be included with lunch and breakfast events.


Peer insights to help identify and manage candidates for treatment with a CDK4/6 inhibitor

Thursday, October 23 • lunch event

Presenter: Kelly McCann, MD, PhD, UCLA

sponsored by Eli Lilly


A 2L Treatment Option for HR+/HER2- aBC or mBC With PIK3CA, AKT1, or PTEN Alterations Following Progression on or After ET ± CDK4/6i

Friday, October 24 • lunch event

Presenter: Kit Lu, MD, UPMC Hillman Cancer Center

sponsored by AstraZeneca


Offering an ADC Treatment for Patients With Pretreated HR+/HER2- mBC and mTNBC

Saturday, October 25 • lunch event

Presenter: Neil Iyengar, MD, Emory University

sponsored by Gilead


View more agendas: Thursday | Friday | Saturday | Sunday | Non-CME

THE PROGRAM

The Lurie Cancer Center's Lynn Sage Breast Cancer Symposium offers 3 days of formal presentations and interactive Q&A sessions.

FACULTY

The Lynn Sage Breast Cancer Symposium is proud of its tradition of attracting a faculty comprised of experts from around the world. Faculty list »

NON-CME EDUCATIONAL ACTIVITIES

Optional, non-CME educational activities are scheduled during times that do not conflict with the Symposium agenda.

Details »

© 2025 Robert H. Lurie Comprehensive Cancer Center